Effects of polyphonic hydroxy flavonoids on gene expression in vitro

Then we selected 90 intersecting targets of the three compounds after the action of S. aureus, and 65 intersecting targets of the three compounds for S. pneumoniae by transcriptome method. These intersecting targets were transformed into heat maps. We then generated KEGG pathway maps by clustering genes exhibiting up- and down-regulated expression or further analysis. Interestingly, myricetin, kaempferol and quercetin all up-regulated the TNF signaling pathway after intracellular bacterial infection According to these results, we propose that the capacity of myricetin, kaempferol and quercetin to decrease the intracellular bacteria is associated with TNF protein, caspase 3 protein and PI3K protein.