Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in mice.
收藏PubMed Central1996-04-30 更新2026-05-02 收录
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https://pmc.ncbi.nlm.nih.gov/articles/PMC39464/
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资源简介：
Macrophages secrete a variety of proteinases that are thought to participate in remodeling of the extracellular matrix associated with inflammatory processes. We have eliminated expression of the macrophage metalloelastase (MME) gene by targeted disruption to assess the role of this protein in macrophage-mediated proteolysis. We found that the macrophages of MME-deficient (MME-/-) mice have a markedly diminished capacity to degrade extracellular matrix components. In addition, MME-/- macrophages are essentially unable to penetrate reconstituted basement membranes in vitro and in vivo. MME is therefore required for macrophage-mediated extracellular matrix proteolysis and tissue invasion. IMAGES:
提供机构：
National Academy of Sciences
创建时间：
1996-04-30
