We report the synthesis of two novel bridged morpholine-proline chimeras 4 and 5, which represent rigid conformationally locked three-dimensional structures wherein the lone pairs of electrons on oxyg
Even though benzodiazepines have a strong position in medicinal chemistry, very few synthetic routes to 1H-1,4-benzodiazepine-3,5(2H,4H)-diones have ever been published and the claimed products have o
First High Resolution Crystal Structure of a Lasso Peptide Descriptor: Bicyclic peptide BI-32169 Authors: Nar, H, Schmid, A, Puder, C, Potterat, O. Deposit date: 2010-06-18 Release date: 2010-09-01 La
Efficient ligand-free palladium catalyzed Mizoroki–Heck reaction allowed the formation of trisubstituted α-trifluoromethylacrylates. The reaction showed good chemical tolerance and furnished moderate
