Transcript Specificity in Yeast Pre-mRNA Splicing Revealed by Mutations in Core Spliceosomal Components

Appropriate expression of most eukaryotic genes requires the removal of introns from their pre-messenger RNAs (pre-mRNAs), a process catalyzed by the spliceosome大多数真核基因的正常表达，需要从前信使RNA（pre-mRNA）中切除内含子，这一过程由剪接体（spliceosome）催化完成。