Gene expression profile of mouse diabetic kidney disease (DKD) injury

Diabetic kidney disease (DKD) is a significant clinical challenge, with an increasing prevalence. Our research identified that fibroblast growth factor 4 (FGF4) secreted by podocytes is a key factor in a mouse model of DKD. Given the importance of FGF4 in DKD-induced kidney injury, we performed gene expression analysis on kidney tissues. This analysis compared db/db model mice with those treated with recombinant FGF4 (rFGF4). The results showed that, compared to the db/db model group, db/db mice treated with long-term rFGF4 demonstrated significant improvements in renal function markers, such as serum urea nitrogen and urinary protein levels.Overall, our findings indicate that FGF4 is a critical regulatory factor in DKD-induced renal injury, providing evidence that it alleviates glomerular damage by inhibiting oxidative stress and apoptosis. To further investigate the role of FGF4 in kidney tissue, we established a diabetic kidney disease (DKD) model in db/db mice. The experiment was divided into two groups: the db/db model group and the rFGF4 treatment group. Subsequently, we performed gene expression profiling on the RNA-seq data from both groups.