CARD

The Comprehensive Antibiotic Resistance Database (CARD; card.mcmaster.ca) combines the Antibiotic Resistance Ontology (ARO) with curated AMR gene (ARG) sequences and resistance-conferring mutations to provide an informatics framework for annotation and interpretation of resistomes. As of version 3.2.4, CARD encompasses 6627 ontology terms, 5010 reference sequences, 1933 mutations, 3004 publications, and 5057 AMR detection models that can be used by the accompanying Resistance Gene Identifier (RGI) software to annotate genomic or metagenomic sequences. New features include the CARD:Live collection of community submitted isolate resistome data and the introduction of standardized 15 character CARD Short Names for ARGs to support machine learning efforts.综合抗生素抗性数据库（Comprehensive Antibiotic Resistance Database, CARD；官网地址为card.mcmaster.ca）将抗生素抗性本体（Antibiotic Resistance Ontology, ARO）与经人工审核整理的抗菌药物抗性基因（AMR gene, ARG）序列及耐药相关突变相结合，搭建用于抗性组（resistome）注释与解析的信息学框架。截至3.2.4版本，CARD共涵盖6627个本体术语、5010条参考序列、1933个突变位点、3004篇相关文献，以及5057个AMR检测模型；配套的抗性基因识别器（Resistance Gene Identifier, RGI）软件可借助这些模型对基因组或宏基因组序列进行注释。该数据库新增了社区提交的分离株抗性组数据集合CARD:Live，同时引入了针对ARG的标准化15字符CARD短名称，以支持机器学习相关研究工作。

搜集汇总

背景与挑战

背景概述

CARD（全面抗微生物药物耐药性数据库）是一个生物信息学数据库，整合了抗微生物药物耐药性本体（ARO）、抗微生物药物耐药性基因序列和突变，用于注释和解释耐药基因组。它包含数千个本体术语、参考序列和检测模型，并提供耐药基因鉴定器（RGI）等工具进行基因组分析。