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Transcriptomic analysis of the effect of trastuzumab in human iPSC-CMs

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NIAID Data Ecosystem2026-03-11 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE116127
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We used human iPSC-CMs generated from healthy individuals and performed RNA-sequencing after 7 days of trastuzumab treatment to examine the mechanism associated with contraction dysfunction in iPSC-CMs after trastuzumab treatment. Transcriptome analysis revealed the key role of an altered energy metabolism pathway for cardiomyocytes in the disease pathogenesis. RNA profiling of 6 samples of trastuzumab- and no drug (control)-treated human iPSC-CMs
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2019-09-26
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