Deciphering the molecular mechanism of NADPH oxidase complex NOX1
收藏DataCite Commons2026-02-23 更新2026-05-03 收录
下载链接：
https://doi.esrf.fr/10.15151/ESRF-ES-2350316067
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资源简介：
Reactive oxygen species (ROS) play a major role in the development and progression of several pathologies such as cancers,
metabolic and immunodeficiency
syndromes and neurosensory disorders. NADPH oxidases (NOX) enzymes form a family of transmembrane proteins involved in critical
pathophysiological processes
through the production of ROS and they have naturally become therapeutic targets. Our goal is to obtain high-resolution protein structures of
the NOX1 complex by
cryogenic electron microscopy (cryo-EM), providing structural data and mechanistic interpretation essential to promote drug design
strategies
提供机构：
European Synchrotron Radiation Facility
创建时间：
2026-02-23
