Copper-Catalyzed Radical-Promoted Aminocyclization of Acrylamides with N‑Fluorobenzenesulfonimide
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https://figshare.com/articles/dataset/Copper-Catalyzed_Radical-Promoted_Aminocyclization_of_Acrylamides_with_i_N_i_Fluorobenzenesulfonimide/4286585
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A facile copper-catalyzed radical aminoarylation of acrylamide with N-fluorobenzenesulfonimide (NFSI) is described. In the presence of copper acetate and 1,10-phenanthroline, a range of isoquinoline-1,3-diones can be constructed in moderate to good yields using NFSI as the amination reagent. Mechanistic studies demonstrated the reaction went through a sequential radical addition and cyclization pathway, which was supported by DFT calculations.
创建时间：
2016-12-05
