Oxcarbazepine influence on the pharmacokinetic profile of Aripiprazole and Dehydroaripiprazole. Raw Data

This dataset contains raw plasma concentration data for aripiprazole and its active metabolite, dehydroaripiprazole, measured in vivo in a rat model, with or without a 5-day oxcarbazepine pretreatment (85 mg/kg/day, 5 days, p.o.). Aripiprazole (8 mg/kg body weight, p.o.) was administered as a single dose to Wistar albino rats (n=12 per group). Concentrations are reported at each time point for every individual rat. In addition, individual pharmacokinetic parameters (Cmax, Tmax, AUC, Kel, half-life, MRT, Vd/F and Cl/F), determined using Phoenix WinNonlin software version 8.5.2 (Pharsight Company, Mountain View, CA, USA), are provided for both experimental groups. The dataset is intended to support pharmacokinetic analyses of drug–drug interactions involving aripiprazole and oxcarbazepine, a mild CYP3A4 isoenzyme inducer.