The association of time-dependent HbA1c with all-cause mortality, CVD events and the combination of CVD and PAD events using multiple Cox-proportional hazards models.

For each model, estimated HRs are shown for the linear component of the non-linear P-spline as well as HRs for HbA1c measurements per 1% increase.*Adjusted for age, sex, time-dependent systolic blood pressure, diastolic blood pressure, albumin, CRP, hemoglobin and previous CVD **.**Cardiovascular disease events: myocardial infarction, percutaneous transluminal coronary angioplasty, aortocoronary bypass, angiographically-proven coronary stenosis ≥50%, ischemic or hemorrhagic cerebral infarction, transient ischemic attack, carotid stenosis and carotid endarterectomy.***Cardiovascular and peripheral arterial disease events: CVD events or significant ultrasound- or angiographically-proven vascular stenosis, percutaneous transluminal angioplasty, peripheral bypass, amputation.