Effects of antipsychotics risperidone and olanzapine on the striatum, liver, pancreas and adipose tissue

Analysis of gene expression in the striatum, the liver, the pancreas, and the visceral adipose tissue of mice treated for 28 days with a daily dose of an atypical antipsychotic: risperidone (1 mg/kg) or olanzapine (3.5 mg/kg). Results provide new insights into the molecular mechanisms underlying antipschotic effects, particularly in tissues relevant for antipsychotic-induced metabolic dysregulation. Antipsychotics are associated with weight gain and other metabolic abnormalities such as hyperglycemia, dyslipidemia and metabolic syndrome. We used microarrays to uncover the underlying molecular mechanisms and identify the key genes involved in AP-induced metabolic effects. Gene expression was assessed by microarray (Affymetrix mouse Clariom S Arrays) in four mice tissues: the striatum, the liver, the pancreas and the adipose tissue. Mice were treated for 28 days with a daily dose of vehicle, risperidone (1 mg/kg) or olanzapine (3.5 mg/kg). Each group included 8 C57BL/6JOlaHsd mice (4 males and 4 females).