Microbial Genomics Raw Sequence and Analysis Data

We aim to better understand the molecular mechanisms of infectious disease and identify potential therapeutic and diagnostic targets by exploiting next-generation genomic data. A major focus is the comparative analysis of genomes obtained from local clinical isolates (Brisbane & Australia) of important human pathogens such as Escherichia coli, Pseudomonas aeruginosa, Staphylococci, Streptococci, Legionella pneumophila and Acinetobacter baumannii.

In particular we are interested in the evolution and mobility of genes encoding virulence factors that are widely conserved amongst bacterial pathogens (e.g., fimbriae, pili and type III and type IV secretion systems and secreted effectors). We have sequenced almost 1,000 bacterial genomes using a variety of different next-generation sequencing technologies (Illumina, SOLiD, 454, PacBio). This collection varies from just sequencing reads right through to annotated complete genomes that we have derived from the data.