Gold-Catalyzed Addition–N‑Boc Cleavage–Cyclization of N,O‑Acetal with Ynamides for Construction of 6‑(tert-Butyldimethylsilyl)oxy-tetrahydropyrrolo[1,2‑c][1,3]oxazin-1-ones

A highly efficient gold-catalyzed approach between N,O-acetals and ynamides for the construction of 6-(tert-butyldimethylsilyl)­oxy-tetrahydropyrrolo­[1,2-c]­[1,3]­oxazin-1-ones was developed. This reaction tolerated a wide range of substituted N,O-acetals and TsN-substituted ynamides, leading to novel heterocycles in moderate to good yields and with excellent diastereoselectivities (dr > 99:1).