Structure of Q148K HIV-1 intasome with Dolutegravir bound

Structure of Q148K HIV-1 intasome with Dolutegravir bound Descriptor: (4R,12aS)-N-(2,4-difluorobenzyl)-7-hydroxy-4-methyl-6,8-dioxo-3,4,6,8,12,12a-hexahydro-2H-pyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazine-9-carboxamide, DNA (25-MER), DNA (27-MER), ... Authors: Shan, Z.L, Passos, D.O, Strutzenberg, T.S, Li, M, Lyumkis, D. Deposit date: 2022-12-27 Release date: 2023-08-09 Last modified: 2024-11-20 Method: ELECTRON MICROSCOPY (2.5 Å) Cite: Mechanisms of HIV-1 integrase resistance to dolutegravir and potent inhibition of drug-resistant variants. Sci Adv, 9, 2023