Cytokine profile of BALF from wild type and RAGE KO mice.

* = Significant difference between strains.All cytokines were significantly up regulated after both LPS and E. coli treatment compared to the control treated. In addition MCP-1 was the only cytokine significantly less increased in RAGE KO mice compared to wild type after LPS challenge. After E. coli treatment all cytokines except KC were increased significantly less in RAGE KO mice compared to wild type mice. The most substantial differences were in IL-6, MCP-1 and TNF-α where levels were 4, 2.9 and 2.4 times higher in wild type BALF compared to RAGE KO BALF.*significant difference between wild type and RAGE KO (pData are mean ±SEM, analyzed by 2-way ANOVA with a Bonferroni post hoc test. (n of 5–7 per group). Abbreviations IL: interleukin, KC: keratinocyte-derived chemokine, TNF: tumor necrosis factor, MIP: macrophage inflammatory protein, MCP: monocyte chemotactic protein.