Recordings and timed stimulation of rat dorsal hippocampal area CA1 and medial prefrontal cortex during behavior and sleep.

Action potentials and local field potentials (LFPs) were simultaneously recorded from the dorsal hippocampus (CA1) and medial prefrontal cortex (mPFC) of nine Long-Evans rats during sleep and behavior. During behavior, the rats explored a rectangular enclosure with two identical objects (spatial object recognition task). Sleep sessions include unperturbed sleep, timed stimulation of motor cortex triggered by hippocampal ripples, and delayed (control) stimulation. Results from the experiments are described in: N. Maingret, G. Girardeau, R. Todorova, M. Goutierre, M. Zugaro (2016). Hippocampo-cortical coupling mediates memory consolidation during sleep. Nature Neuroscience 19(7):959-64. R. Todorova and M. Zugaro (2019). Isolated cortical computations during delta waves supports memory consolidation. Science (in press). The data set includes # sessions, each consisting of pre-task sleep, task, and post-task sleep (~# min sleep sessions). Hippocampal and cortical signals were recorded using sixteen independently movable tetrodes (64 channels). Data include sorted spikes (times, clusters, featres, and full waveforms), LFPs (at 1250 Hz), positions (coordinates of head-mounted LEDs), and experiment descriptions. They are provided in the standard, open format of NeuroSuite (L. Hazan, http://neurosuite.sourceforge.net, see Hazan et al., 2006). Data analyses described in the above articles used our free (GPL-licensed) Freely Moving Animal Toolbox (FMAToolbox, M. Zugaro, http://fmatoolbox.sourceforge.net) and custom scripts provided in the archive.