KRasG12C in complex with GDP and JDQ443
收藏Protein Data Bank Japan2024-10-23 更新2026-04-19 收录
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https://pdbj.org/mine/summary/7r0m
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KRasG12C in complex with GDP and JDQ443 Descriptor: 1-[6-[4-(5-chloranyl-6-methyl-1~{H}-indazol-4-yl)-5-methyl-3-(1-methylindazol-5-yl)pyrazol-1-yl]-2-azaspiro[3.3]heptan-2-yl]propan-1-one, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... Authors: Ostermann, N. Deposit date: 2022-02-02 Release date: 2022-04-27 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.611 Å) Cite: Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C. Cancer Discov, 12, 2022
创建时间：
2022-02-02
