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Diverse Cyclization Catalyzed by In(OTf)<sub>3</sub> for the Convergent Assembly of Substituted Tetrahydrofurans and Tetrahydropyrans

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NIAID Data Ecosystem2026-03-06 收录
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A novel In(OTf)3-catalyzed (3,5) oxonium-ene type cyclization for the facile construction of various multisubstituted tetrahydrofurans and tetrahydropyrans was successfully developed. Further mechanistic investigations unveiled an In(OTf)3-catalyzed skeletal reorganization of the tetrahydrofuran to its thermodynamic isomer under thermal conditions.

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2016-08-20
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