SOX10 binds CDH19 gene promoter

Based on studies in mouse, the transcription factor SOX10, essential for migration of neural crest cells during formation of the enteric nervous system, binds CDH19 gene promoter and stimulates CDH19 transcription. Cdh19 knockdown results in retarded sacral migration of neural crest cells, while re-expression of Cdh19 partially rescues retarded migration of Sox10-null neural crest cells (Huang et al. 2022). Binding of SOX10 to the CDH19 gene promoter was also demonstrated in mouse melanocytes, but Cdh19 was not found to be differentially expressed in melanocytes upon Sox10 gene knockout (Fufa et al. 2015).

基于对小鼠的研究，转录因子SOX10（在肠神经系统形成过程中对神经嵴细胞的迁移至关重要）与CDH19基因启动子结合，并刺激CDH19的转录。Cdh19敲低导致神经嵴细胞骶骨迁移延迟，而Cdh19的重表达部分挽救了SOX10基因敲除的神经嵴细胞迁移延迟（Huang等，2022年）。SOX10与CDH19基因启动子的结合也在小鼠黑色素细胞中得到证实，但CDH19在Sox10基因敲除后并未发现其在黑色素细胞中的差异表达（Fufa等，2015年）。