Samples information and classification.

Sample Information: Includes sample name, age, gender, CCP/RF values, and clinical RA diagnosis. This was provided by ARUP laboratory. Classification in each experiment: ○ HDC Peak Ratio: The ratio of the HSA peak at 63°C to the Ig peak at 71°C ○ HDC group: the group is assigned based on HDC peak ratio. The HPR has peak ratio > 1.00, the LPR has peak ratio < 1.00 ○ PTM group: the group is assigned based on hierarchical order of the Inferno Heatmap in Fig 5B. It is used for analysis shown in Fig 5C. Experiment raw data filename: the directory of the HDC and MS filenames in relation to the sample name. The MS raw files are available for download at the chorusporject.org (project ID: 1739, experiment ID:3632). The HDC raw files are available upon request. Sample Information: Includes sample name, age, gender, CCP/RF values, and clinical RA diagnosis. This was provided by ARUP laboratory. Classification in each experiment: ○ HDC Peak Ratio: The ratio of the HSA peak at 63°C to the Ig peak at 71°C ○ HDC group: the group is assigned based on HDC peak ratio. The HPR has peak ratio > 1.00, the LPR has peak ratio < 1.00 ○ PTM group: the group is assigned based on hierarchical order of the Inferno Heatmap in Fig 5B. It is used for analysis shown in Fig 5C. ○ HDC Peak Ratio: The ratio of the HSA peak at 63°C to the Ig peak at 71°C ○ HDC group: the group is assigned based on HDC peak ratio. The HPR has peak ratio > 1.00, the LPR has peak ratio < 1.00 ○ PTM group: the group is assigned based on hierarchical order of the Inferno Heatmap in Fig 5B. It is used for analysis shown in Fig 5C. Experiment raw data filename: the directory of the HDC and MS filenames in relation to the sample name. The MS raw files are available for download at the chorusporject.org (project ID: 1739, experiment ID:3632). The HDC raw files are available upon request. (XLSX)