Hydrogel Database(HD)

Hydrogel is a polymer system with a three-dimensional network structure containing a large amount of water formed by a simple reaction of one or more monomers, which can be classified into various types according to the structure, cross-linking mode, polymer composition and so on. The application of hydrogel is very wide, covering all aspects of life, its physical properties are conducive to drug delivery, can be better in the local area in accordance with the designed rate of drug release, but also through a variety of functional modifications to achieve responsive on-demand drug release. In recent years, hydrogels have been widely studied as drug delivery carrier materials, and among many marketed products, temperature-sensitive and pH-sensitive hydrogels have a broad market. In addition to this, hydrogels can be combined with other drug delivery technologies, such as for the preparation of microneedles. Hydrogels can also be used to prepare nanoparticles, which have an elastic hydrogel shell and exhibit different cellular uptake behavior than rigid nanoparticles. For subsequent formulation improvement and delivery mode studies to select suitable hydrogel materials as intermediates for transdermal delivery modes, we constructed a hydrogel database based on an extensive literature review. The database covers numerous entries of hydrogel materials such as combination methods, classes, materials, preparation methods, solubility, biocompatibility, mechanical properties, drug loading capacity, drug release, indications, and so on. China's hydrogel-related drug research and development still needs further development, and hydrogel transdermal drug delivery has a broad prospect. Therefore, hydrogel materials with strong drug loading capacity and good drug release effect can be screened directly in this database system as a solid foundation for subsequent research, which can make a certain contribution to drug development.水凝胶（Hydrogel）是一类由一种或多种单体经简单反应制备得到的、富含大量水分的三维网络结构聚合物体系。根据结构、交联方式、聚合物组成等不同维度，可将水凝胶划分为多种类别。水凝胶的应用场景十分广泛，覆盖日常生活的诸多领域。其物理特性适配药物递送需求：可在局部区域按照设计速率实现药物释放，还可通过多种功能化修饰手段达成响应型按需药物释放效果。近年来，水凝胶作为药物递送载体材料受到广泛研究，在众多已上市的相关产品中，温敏型与pH敏型水凝胶拥有广阔的市场空间。除此之外，水凝胶可与其他药物递送技术相结合，例如用于制备微针；也可用于制备具备弹性水凝胶外壳的纳米粒，其细胞摄取行为与刚性纳米粒存在显著差异。为在后续的制剂优化与递送方式研究中筛选适配的水凝胶材料作为经皮递送途径的中间体，本研究通过系统性文献调研构建了水凝胶数据库。该数据库涵盖海量水凝胶材料相关条目，包括组合方法、材料类别、原料组成、制备方法、溶解性、生物相容性、力学性能、载药量、药物释放特性、适应症等多项信息。我国水凝胶相关药物研发仍有待进一步推进，而水凝胶经皮给药技术拥有广阔的应用前景。因此，可直接在本数据库系统中筛选具备高载药量与优良药物释放效果的水凝胶材料，为后续研究奠定坚实基础，可为药物开发事业贡献一定价值。

搜集汇总

背景与挑战

背景概述

Hydrogel Database(HD)是一个基于文献综述构建的水凝胶材料数据库，旨在为透皮给药模式筛选合适的水凝胶材料。它涵盖了水凝胶的组合方式、类别、材料、制备方法、溶解度、生物相容性、机械性能、载药能力、药物释放和适应症等多个属性条目，为后续药物研发提供基础支持。该数据库特别关注温度敏感和pH敏感水凝胶的应用，以促进药物递送领域的研究和发展。