Darapladib pharmacokinetic and pharmacodynamic parameters in healthy Chinese and Western subjects.

a = Values are expressed as geometric mean [Coefficient of Variation %]
b = Values are expressed as mean (95% Confidence Interval)
Ro = Observed accumulation ratio; Rp = Predicted accumulation ratio; Rs = Steady-state accumulation ratio; RCmax = Cmax accumulation ratio; AUC(0-τ) = Area under the concentration-time curve over the dosing interval; AUC(0-∞) = Area under the concentration-time curve from time zero (pre-dose) extrapolated to infinite time; CI: Confidence Interval; IC50: darapladib plasma concentration causing 50% inhibition of plasma Lp-PLA2 activity. Data in Western subjects from separate study LPL112498 (Clinical Trial. Gov: NCT00743860).
Darapladib pharmacokinetic and pharmacodynamic parameters in healthy Chinese and Western subjects.