The interaction of dietary pectin, inulin, and psyllium with copper nanoparticle induced changes to the cardiovascular system

Blood plasma antioxidant capacity of water (ACW) and lipid soluble antioxidant capacity (ACL), malondialdehyde, catalase measured in the hearts of rats fed with experimental diets. The cumulative concentration-response curves to acetylcholine in the isolated thoracic arteries dissected from rats fed with experimental diets. Effects of iNOS inhibition on the cumulative concentration-response curves to acetylcholine in the isolated thoracic arteries dissected from rats fed with experimental diets. Effects of COX-1 and COX-2 inhibition on the cumulative concentration-response curves to acetylcholine in the isolated thoracic arteries dissected from rats fed with experimental diets. Effects of COX-2 inhibition on the cumulative concentration-response curves to acetylcholine in the isolated thoracic arteries from rats fed with experimental diets. Cyclooxygenase-2 measured in the aortic rings of rats fed with experimental diets. Rats were randomly divided into 10 groups. The first two groups were fed a control diet that contained cellulose, and a mineral mixture with standard or enhanced content of CuCO3. Experimental groups were fed a diet supplemented with CuNPs (6.5 or 13 mg/kg) and combined with different types of fibre (cellulose, pectin, inulin or psyllium).