Open Science Data Repository

The NASA Open Science Data Repository (OSDR) is a comprehensive platform designed to maximize the scientific value of biological experiments conducted in space or under spaceflight-like conditions to enable future missions to the Moon and Mars. It provides a robust infrastructure for users to upload, download, store, analyze, and visualize biological and environmental data collected from space-relevant experiments involving organisms such as mice, fruit flies, plants, and microbes. OSDR datasets are meticulously curated using standardized ontologies and metadata formats that are normalized across studies. Such standards maximize the AI-readiness of these precious data thereby improving search capabilities, enabling cross-dataset analyses, and enhancing our knowledge about the impacts of spaceflight on terrestrial biology so we can develop effective mitigation strategies for long-duration spaceflight. OSDR services the life sciences community through its data repository and visualization suite, consisting of omics data from GeneLab and physiological, phenotypic, behavioral, bioimaging, and environmental data from the Ames Life Sciences Data Archive (ALSDA). These resources not only advance our understanding of how biological systems respond to space conditions, including microgravity and radiation, but also have direct applications for human health on Earth, such as improving treatments for osteoporosis, cardiovascular disease, aging, and microbial infections.

GeneLab是一个交互式、开放获取的资源平台，科学家们可在此上传、下载、存储、搜索、共享、转移和分析来自航天器和相应模拟实验的组学数据。用户可在数据存储库中探索GeneLab数据集，利用分析平台进行数据解析，并通过协作工作空间创建协作项目。GeneLab致力于促进和提升信息共享，激发创新，并加速从极为罕见且宝贵的空间生物学实验中获取科学发现的步伐。通过GeneLab进行的发现已经开启并将继续深化我们对生物学的理解，推进基因组学领域的发展，并有助于发现疾病的治疗方法、创造更优良的诊断工具，最终使宇航员能够更好地承受长时间航天飞行的严酷考验。GeneLab通过提供全面协调的表观遗传学、基因组学、转录组学、蛋白质组学和代谢组学数据，以及描述每个航天飞行和空间相关实验的必要元数据，帮助科学家们理解生命的基本构建模块——DNA、RNA、蛋白质和代谢物——在微重力、辐射和其他空间环境因素作用下的变化。通过精心策划和实施数据标准最佳实践，用户能够结合单个GeneLab数据集，获得关于航天飞行对生物学影响的全新、全面的洞察。以此方式，GeneLab扩展了从空间生物实验中获得的科学知识，使全球的科学家能够从这些无价数据中取得新的发现并发展新的假设。