Synthesis of β-Fluoroamines by Lewis Base Catalyzed Hydrofluorination of Aziridines
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https://figshare.com/articles/dataset/Synthesis_of_Fluoroamines_by_Lewis_Base_Catalyzed_Hydrofluorination_of_Aziridines/2529352
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资源简介：
Lewis base catalysis promotes the in situ generation
of amine-HF
reagents from benzoyl fluoride and a non-nucleophilic alcohol. The
hydrofluorination of aziridines to provide β-fluoroamines using
this latent HF source is described. This protocol displays a broad
scope with respect to aziridine substitution and N-protecting groups. Examples of regio- and diastereoselective ring
opening to access medicinally relevant β-fluoroamine building
blocks are presented.
创建时间：
2012-04-20
