CDC42:GTP recruits DIAPH2-2 to kinetochores
收藏reactome.org2025-01-16 收录
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Activated CDC42 (CDC42:GTP) can localize to kinetochores of metaphase cells and recruit DIAPH2 transcriptional isoform DIAPH2-2 (DIA-12C, mDia3) to kinetochores. The CDC42:GTP:DIAPH2-2 complex regulates the attachment of microtubules to kinetochores (Yasuda et al. 2004).
活化型 CDC42(CDC42:GTP)能够定位于有丝分裂细胞的着丝粒,并招募 DIAPH2 转录型异构体 DIAPH2-2(DIA-12C,mDia3)至着丝粒。CDC42:GTP:DIAPH2-2 复合物调节微管与着丝粒的结合(Yasuda 等,2004 年)。
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