CDC42:GTP recruits DIAPH2-2 to kinetochores

Activated CDC42 (CDC42:GTP) can localize to kinetochores of metaphase cells and recruit DIAPH2 transcriptional isoform DIAPH2-2 (DIA-12C, mDia3) to kinetochores. The CDC42:GTP:DIAPH2-2 complex regulates the attachment of microtubules to kinetochores (Yasuda et al. 2004).活化型 CDC42（CDC42:GTP）能够定位于有丝分裂细胞的着丝粒，并招募 DIAPH2 转录型异构体 DIAPH2-2（DIA-12C，mDia3）至着丝粒。CDC42:GTP:DIAPH2-2 复合物调节微管与着丝粒的结合（Yasuda 等，2004 年）。