Transciptome changes in relation to manic episode. Transciptome changes in relation to manic episode

The present study focused on manic episode in bipolar disorder (BD) patients, and to investigate state-specific transcriptome alterations between acute episode and remission, including mRNAs, long non-coding RNAs (lncRNAs), and miRNAs using Affymetrix Human Transcriptome Array 2.0. Overall design: Six BD patients were enrolled with clinical and biological samples collected at both acute and remission status following-up for at least two-months. We extracted RNA from two time points and used Affymetrix Human Transcriptome 2.0 array to capture transcriptome data underwent intra-individual comparison.