Crystal structure of CD73 (ecto-5'-nucleotidase) in complex with the AOPCP derivative PSB19427 in the closed state

Crystal structure of CD73 (ecto-5'-nucleotidase) in complex with the AOPCP derivative PSB19427 in the closed state Descriptor: 5'-nucleotidase, ZINC ION, [[(2~{R},3~{S},4~{R},5~{R})-5-[2-chloranyl-6-[[4-[1-(2-fluoranylethyl)-1,2,3-triazol-4-yl]phenyl]methyl-propyl-amino]purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]methylphosphonic acid Authors: Strater, N, Moschuetz, S, Dobelmann, C, Schmies, C.C, Jacobson, K.A, Muller, C.E, Junker, A. Deposit date: 2024-11-11 Release date: 2025-11-19 Last modified: 2026-08-12 Method: X-RAY DIFFRACTION (2.911 Å) Cite: Fluorine-18-Labeled Nucleotide Analogs Targeting Ecto-5'-Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors. Angew.Chem.Int.Ed.Engl., 65, 2026