Candidate variants identified through whole exome sequencing in 7 multiplex families.

Ref = reference allele, Alt = alternate allele. Alt Freq = alternate allele frequency (consensus frequency for the alternate allele from 1000 Genomes and/or Exome Sequencing Project, as described in the Methods), LOD = maximum LOD score for linkage markers found within a 10Mb window of the sequencing variant, Unaff = number of sequenced unaffected individuals who carry the variant, logFC = log fold change of expression differential (N/A indicates no expression data is available for the gene), FDR = false discovery rate-adjusted p-value. All variants are predicted to be non-synonymous exonic variants except the deletion at the end of the Table. A plus sign (+) denotes a damaging prediction. For variants segregating in families B, D, or G, a (§) indicates that variant was also shared by an individual in the same family with a probable or possible IA or an abdominal aortic aneurysm.Candidate variants identified through whole exome sequencing in 7 multiplex families.