Identification of direct targets and modified bases of RNA cytosine methyltransferases
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Identification of direct targets and modified bases of RNA cytosine methyltransferases
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2013-04-21
相关数据集
The RNA N6-methyladenosine regulates chromatin remodeling and transcription [seq_mettl3ChIP]. The RNA N6-methyladenosine regulates chromatin remodeling and transcription [seq_mettl3ChIP]
The N6-methyladenosine (m6A) has been shown to regulate stability and translation of messenger RNA (mRNA) in various biological processes. Here, we show that the knockout of the m6A writer Mettl3 or a
NIAID Data Ecosystem80
Transcriptome Mapping of Internal N7-methylguanosine Methylome in Mammalian mRNA
N7-methylguanosine (m7G) is a positively charged, essential modification at the 5′ cap of eukaryotic mRNA, regulating mRNA export, translation, and splicing. m7G also occurs internally within tRNA and
NIAID Data Ecosystem40
Single-base resolution methylome of 5-Methylcytosine in human and mouse transcriptome. Single-base resolution methylome of 5-Methylcytosine in human and mouse transcriptome
mRNAs of siCTRL, siNSUN2 and ALYREF-RIP HeLa cells, and multiple mouse tissues were purified using oligo (dT)-conjugated magnetic beads followed by RiboMinus treatement. mRNAs were fragmented to ~200
NIAID Data Ecosystem40
Identifying the impact of NSUN6 mutants on tRNA methylation
mRNA m5C, which has recently been implicated in the regulation of mRNA mobility, metabolism, and translation, plays important regulatory roles in various biological events. Two types of m5C sites are
NIAID Data Ecosystem50
m6A mRNA modification is a rheostat to maintain colonic epithelial cell homeostasis [bulkRNA-seq]. m6A mRNA modification is a rheostat to maintain colonic epithelial cell homeostasis [bulkRNA-seq]
The function of m6A modification in colonic epithelial cells has been validated in our study that depletion of METTL14 in colonic epithelial cells triggers cell death. To further explore the biologica
NIAID Data Ecosystem40
