The causative effect of CXCR7 on experimental autoimmune prostatitis injury and fibrosis

The purpose of this study is to further understand the changes in mRNA expression in the prostate tissue of EAP mice after the use of VUF11207. After establishing the EAP mouse model, the experimental group was intraperitoneally injected with VUF11207, while the control group was intraperitoneally injected with an equal amount of DMSO solvent. After continuous injection for 14 days, the mRNA expression in the mouse prostate was sequenced and analyzed. Using RNA-Seq technology, a large number of differentially expressed genes were identified at the whole-genome level. Our study suggests that compared to the control group, under the action of VUF11207, CXCR7 can cause prostate epithelial cell damage and fibrosis. Overall design: The mice used to establish the EAP model were divided into two groups. The experimental group was injected intraperitoneally with VUF11207 (5mg/kg/day), while the control group was injected intraperitoneally with an equal amount of DMSO. After continuous intraperitoneal injections for 14 days, the mice were euthanized, and the prostate tissues were collected for RNA-Seq analysis of mRNA expression levels.