HTR1A binds HTR1A antagonists

The serotonin 1A receptor (HTR1A), encoded by the HTR1A gene, binds the neurotransmitter serotonin (5-hydroxytryptamine, 5HT). It is a G protein-coupled receptor (GPCR), coupled to the Gi protein, that mediates inhibitory neurotransmission. HTR1A is the most widespread of all the HTR1 receptors, mainly throughout the central nervous system. Dysfunctions associated with abnormal HTR1A neurotransmission are linked to several psychiatric disorders, including anxiety, depression, and movement disorders.

血清素1A受体（HTR1A），由HTR1A基因编码，与神经递质血清素（5-羟色胺，5HT）结合。它是一种G蛋白偶联受体（GPCR），与Gi蛋白偶联，介导抑制性神经传递。HTR1A是所有HTR1受体中最广泛的，主要分布于中枢神经系统。与异常HTR1A神经传递相关的功能障碍与多种精神疾病相关，包括焦虑、抑郁和运动障碍。