PDL1 expression constitutes a macrophage phagocytosis checkpoint in aggressive B-cell lymphoma

Human Xenium spatial transcriptomics dataset of diffuse large B-cell lymphoma Overview This Zenodo record contains human Xenium spatial transcriptomics data generated from diffuse large B-cell lymphoma samples. The dataset includes two Xenium slides: * slide 0028954* slide 0038329 For each slide, selected raw Xenium output files are provided, including the cell-feature matrix, cell metadata, transcript coordinates, cell boundaries, nucleus boundaries, and run metrics. Processed cell-level metadata are also provided. File structure Human_Xenium_DLBCL_data_2026/├── README.md├── DLBCL_Xenium_cell_metadata_202606.csv.gz├── DLBCL_Xenium_panel_metadata_202606.csv.gz├── DLBCL_Xenium_sample_metadata_202606.csv.gz├── DLBCL_Xenium_processed_objects_202606.rds├── DLBCL_Xenium_raw_slide0028954_202606.tar.gz└── DLBCL_Xenium_raw_slide0038329_202606.tar.gz Raw Xenium data Each raw slide package contains the following files: cell_feature_matrix.h5cells.parquetcell_boundaries.parquetnucleus_boundaries.parquettranscripts.parquetmetrics_summary.csv Description of included raw files: * cell_feature_matrix.h5: cell-by-gene expression matrix generated by the Xenium pipeline.* cells.parquet: cell-level information and spatial cell coordinates.* cell_boundaries.parquet: cell boundary polygons.* nucleus_boundaries.parquet: nucleus boundary polygons.* transcripts.parquet: transcript-level coordinates and gene identities.* metrics_summary.csv: run-level quality control metrics. Morphology image files, morphology focus folders, Zarr-format files, and auxiliary per-cycle image folders are not included in this Zenodo record due to file size and data governance considerations. Processed cell metadata The file DLBCL_Xenium_cell_metadata_202606.csv.gz contains processed cell-level metadata. Diagnostic groups The dataset includes tissue regions from the following diagnostic groups: * PT_DLBCL* IS_DLBCL* DLBCL_NOS_Extranodal* DLBCL_NOS_Nodal* LymphNode Contact Ningxuan CuiUniversity of Zurich Anne MüllerUniversity of Zurich