Bone morphogenetic protein increases tau phosphorylation and secretion in tauopathies in an APOE dependent manner

To investigate the contribution of APOE genotype on neuronal transcription of key Alzheimer and BMP-relevant genes Overall design: Neuronal cells were differentiated from two different IPSC lines and isogenic controls (4 lines total) using the NGN2 viral protocol. Cells were grown for 35 days to ensure maturity prior to collection for RNA-seq