The relationships between anemia and ischemic stroke on RNA expression level

Anemia was characterized as a risk factor of IS because the direct connection between central nervous system, blood supply, and tissue oxygen delivery. As the key oxygen-carrying molecule in the blood, hemoglobin (Hb) may be decisive for the destiny of penumbral area or influence the brain recovery and neurologic function, which could finally affect the outcome of IS. Whole blood RNA sequencing of 4 ischemic stroke patients in recovery stage (1 anemia and 3 non-anemia) are performed at two different time points with one-month interval. The goal of the experiment is to identified the relationship between anemia-associated gene expressions and IS recovery outcomes.