<strong>Supplemental Table 4</strong>

<strong>Supplemental Table 4. Gut microbiome and metabolome after 7 days treatment of tacrolimus</strong>.<strong> A</strong>) Taxonomic assignment of gut microbiota was performed to compare to gut microbiota after 2 days of tacrolimus treatment. Gut metabolome after <strong>B</strong>) 2 days of tacrolimus was compared to gut metabolome after <strong>C</strong>) 7 days of treatment. To indicate the significantly affected pathways after 7 days of tacrolimus treatment, <strong>D</strong>) pathway enrichment analysis was performed using metabolite set enrichment analyses (MSEA) (Xia and Wishart, 2010). Metabolites of the intraluminal stool using CE/MS (capillary electrophoresis-mass spectrometry) (Kawamura et al., 2018; Matsumoto et al., 2014; Sugahara et al., 2017).