Upregulation of different classes of genes in cutaneous SCC cells by KGF as determined by DNA microarray analysis.

Three KGFR-positive SCC cell lines were serum-starved and treated with rKGF (10 ng/ml) for 24 h. Total RNA was analyzed for differential gene expression by Affymetrix microarray. The genes with the hybridization signal above the median of the signal intensity distribution in at least one sample were analyzed. The genes with more than 1.5 fold (150% of control) change in the expression level were included in the table.1The data represents the fold-change of hybridization signal of KGF-treated cells over the untreated cells for the indicated gene.2The data represents the fold-change of hybridization signal between untreated SCC cells and normal epidermal keratinocytes for the indicated gene. The negative fold-change indicates decrease in hybridization signal in SCC cells compared to normal keratinocytes. ∼ indicates positive or negative fold-change less than 1.5.