The Fitness Consequences of Aneuploidy Are Driven by Condition-Dependent Gene Effects

Aneuploidy is a hallmark of tumor cells, and yet the precise relationship between aneuploidy and a cell’s proliferative ability, or cellular fitness, has remained elusive染色体非整倍性（aneuploidy）是肿瘤细胞的标志性特征，然而其与细胞增殖能力或细胞适合度之间的确切关联，迄今仍未得到清晰阐明。