BP Figure 5: Liver transcriptome analysis in P446L mice after 20 wk on HFHSD -/+ AZD1656: lesser impact of AZD1656 treatment compared with P446L genotype.

A) Venn diagram for differentially expressed genes (DEGs adjusted P < 0.05) by AZD1656 treatment: PP- vs PP+ (26 DEGs) and LL- vs LL+ (13 DEGs); or by genotype PP- vs LL- (150 DEGs), PP+ vs LL+ (25 DEGs). Blue, common genes similar direction; red, common genes opposite direction. B) Ingenuity Pathway Analysis: showing top enriched pathways by genotype (PP-vs LL-) or by AZD1656 treatment (PP-/PP+ or LL-/LL+) showing Z-scores for pathway flux and –log (P-value). C-E) Genes that are differentially expressed by PP- vs LL- genotype show smaller but directionally similar changes by AZD1656 treatment in PP mice. Z-scores for gene counts and median and range of genes shown. **P

A) 依据AZD1656处理（PP-与PP+间差异表达基因[调整P值<0.05]：26个差异表达基因；LL-与LL+间差异表达基因：13个差异表达基因）；或通过基因型（PP-与LL-：150个差异表达基因；PP+与LL+：25个差异表达基因）进行韦恩图展示。蓝色代表具有相似方向的共同基因；红色代表具有相反方向的共同基因。B) Ingenuity通路分析：展示按基因型（PP-与LL-）或AZD1656处理（PP-/PP+或LL-/LL+）富集的通路，并显示通路流量Z值和-对数P值。C-E) 由PP-与LL-基因型差异表达的基因在PP小鼠中经AZD1656处理后表现出较小但方向上相似的变动。展示基因计数Z值、中位数和基因范围。**P