Metal-Free Indole–Phenacyl Bromide Cyclization: A Regioselective Synthesis of 3,5-Diarylcarbazoles
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资源简介：
A metal-free, simultaneous triple C–C coupling cyclization reaction between phenacyl bromides and indoles is discovered in a highly regioselective fashion to furnish 3,5-diarylcarbazoles. DMAP is utilized as the only reagent for the unusual and rapid cyclization reaction to furnish all new carbazole compounds through installation of a great diversity of substituents. A plausible radical mechanism for the new reaction is predicted by conducting various control experiments, competitive reactions, furoindole formation, and ESI-MS analyses of the ongoing cyclization reaction.
创建时间：
2020-10-02
