Exocytosis of azurophil granule membrane proteins

Azurophil or primary granules were originally defined by their high content of myeloperoxidase (MPO) and their affinity for the basic dye azure A (Spicer & Hardin 1969). Azurophil granules are generally described as spherical. Like lysosomes, they contain CD63 in their membrane (Cham et al. 1994) but are regarded as specialized secretory granules rather than lysosomes (Cieutat et al. 1998). Azurophil granules undergo limited exocytosis in response to stimulation (Sengelov et al. 1993, Faurschou et al. 2002), their primary role is believed to be killing and degradation of engulfed microbes in the phagolysosome (Joiner et al. 1989).

嗜天青颗粒或初级颗粒最初是根据其高含量的髓过氧化物酶（MPO）及其对碱性染料天青A（Spicer & Hardin 1969）的亲和力而定义的。嗜天青颗粒通常被描述为球形。与溶酶体类似，它们的膜中含有CD63（Cham等，1994年），但被视为专门的分泌颗粒而非溶酶体（Cieutat等，1998年）。在受到刺激时，嗜天青颗粒会经历有限的胞吐作用（Sengelov等，1993年，Faurschou等，2002年），其主要功能被认为是在吞噬溶酶体内杀死和降解吞噬的微生物（Joiner等，1989年）。