mRNA sequence analysis of eutopic and ectopic endometrium in the same patients with adenomyosis

In this study, we explored differences in gene expression between the eutopic and ectopic endometrium in the same patients with adenomyosis The pathological specimens of patients with adenomyosis were obtained from Shengjing Hospital. This study was approved by the ethics committee of Shengjing hospital (serial number: 2022PS696K). The patients were informed and provided with written informed consents for this study. The patients underwent total hysterectomy due to adenomyosis or cervical intraepithelial neoplasia (CIN). However, the pathological findings confirmed adenomyosis in all cases. Clinical data, including age and fertility status, coexisting with adenomyosis, are available. RNA samples of eutopic and ectopic endometrium were extracted from the patients’ specimens and mRNA sequence analysis was performed.