Deciphering the distinct transcriptomic and gene regulatory map in adult macaque basal ganglia cells

The basal ganglia are a complex of interconnected subcortical structures located beneath the mammalian cerebral cortex. The degeneration of dopaminergic neurons in the basal ganglia is the primary pathological feature of Parkinson's disease. We utilized high-throughput transcriptomic and epigenomic analysis to profile over 270,000 single-nucleus cells to create a cellular atlas of the basal ganglia, characterizing the cellular composition of four regions of basal ganglia in adult macaque brain, including the striatum (STR), substantia nigra (SN), globus pallidum (GP), and amygdala (AMY).