The Thr92Ala-DIO2 polymorphism affects outcomes in LT4-treated women

Context: The Thr92Ala-DIO2 polymorphism may affect hypothyroid patients’ responses to levothyroxine (LT4) treatment.

Objective: To study whether the Thr92Ala-DIO2 polymorphism affects hypothyroid patients’ responses to levothyroxine (LT4) treatment.

Design: Secondary analysis of a randomized intervention study.

Setting: Primary care center.

Patients or Other Participants: 109 hypothyroid women aged 21-70 years with normal TSH levels grouped in homozygous Thr92-DIO2 (THR; n=39) and homozygous Ala92-DIO2 plus heterozygous (ALA; n=70) groups.

Intervention: Change in LT4 dose.

Main Outcome Measure: Cognitive testing examined declarative memory (paragraph recall) and executive function (letter cancelation, trail making, Iowa gambling task, N-back number correct/incorrect, and subject ordered pointing). Mood and health status were assessed with the profile of mood states (POMS) questionnaire, affective lability scale (ALS), and thirty-six item short-form health survey (SF-36...