Effect of Exercise Preconditioning on Myocardial Content of Sphingosine1-phosphate and its Mechanism in Rats after Exhaustive Exercise

Dataset: Raw data and statistical analysis for "Exercise Preconditioning Protects the Heart via the S1P-MAPK Signaling Axis in a Rat Model"Description:This dataset contains all raw data and statistical analysis supporting the findings of the study investigating the cardioprotective mechanism of exercise preconditioning (EP) through the Sphingosine-1-phosphate (S1P) - MAPK signaling pathway in a rat model.Study Design Overview:Male Sprague-Dawley rats were randomly assigned to four experimental groups:Control (C): Sedentary + exhaustive exerciseExercise Preconditioning (EP): EP + exhaustive exerciseEP + W146: EP with S1PR1 antagonist + exhaustive exerciseEP + PD98059: EP with MEK1/2 inhibitor + exhaustive exercisePrimary endpoints included myocardial apoptosis rate, with secondary outcomes of myocardial injury markers, S1P content, and MAPK pathway activation.