Transcriptomics of CD29+/CD44+ cells isolated from hPSC retinal organoids reveals a cell population with retinal progenitor and Müller glia characteristics.. Transcriptomics of CD29+/CD44+ cells isolated from hPSC retinal organoids reveals a cell population with retinal progenitor and Müller glia characteristics.

Müller glia play very important and diverse roles in retinal homeostasis and disease, bur very little is known of their development during human retinal embryogenesis. Since they share several markers with retinal progenitors, they are often considered as a different cell population. In this study we isolated CD29+/CD44+cells from retinal organoids formed by hEPSC cells in vitro, and examined their transcriptome profile at various stages of organoid development to identify their transcriptomic profile.