Affymetrix SNP array data for kidney transplant samples

Tacrolimus (TAC) is an immunosuppressant widely used in kidney transplantation. TAC displays considerable inter-individual variability in pharmacokinetics (PK). Genetic and clinical factors play important roles in TAC PK. To define genetic factors associated with tacrolimus blood trough concentration, we performed a genome-wide association study of renal transplant samples from 251 Chinese renal transplant recipients. We identified 23 single nucleotide polymorphisms (SNPs) related to TAC PK variability. All 23 genome-wide significant SNPs (p<5E-8) were located on chromosome 7, including rs776746. These findings suggest that these SNPs may be associated with the unexlained TAC PK variability in renal transplant recipients and require further investigation. Affymetrix SNP arrays were performed according to the manufacturer's directions on DNA extracted from peripheral blood samples. Single nucleotide polymorphism analysis of Affymetrix 800K SNP arrays was performed for 251 renal transplant cases.