Bertram2004_PancreaticBetaCell_modelB

This a model from the article:

Calcium and glycolysis mediate multiple bursting modes in pancreatic islets.

Bertram R, Satin L, Zhang M, Smolen P, Sherman A.
Biophys J2004 Nov;87(5):3074-87
15347584,

Abstract:

Pancreatic islets of Langerhans produce bursts of electrical activity when
exposed to stimulatory glucose levels. These bursts often have a regular
repeating pattern, with a period of 10-60 s. In some cases, however, the bursts
are episodic, clustered into bursts of bursts, which we call compound bursting.
Consistent with this are recordings of free Ca2+ concentration, oxygen
consumption, mitochondrial membrane potential, and intraislet glucose levels
that exhibit very slow oscillations, with faster oscillations superimposed. We
describe a new mathematical model of the pancreatic beta-cell that can account
for these multimodal patterns. The model includes the feedback of cytosolic Ca2+
onto ion channels that can account for bursting, and a metabolic subsystem that
is capable of producing slow oscillations driven by oscillations in glycolysis.
This slow rhythm is responsible for the slow mode of compound bursting in the
model. We also show that it is possible for glycolytic oscillations alone to
drive a very slow form of bursting, which we call "glycolytic bursting."
Finally, the model predicts that there is bistability between stationary and
oscillatory glycolysis for a range of parameter values. We provide experimental
support for this model prediction. Overall, the model can account for a
diversity of islet behaviors described in the literature over the past 20 years.

This model was taken from the
CellML repository and automatically converted to SBML.

The original model was:

Bertram R, Satin L, Zhang M, Smolen P, Sherman A. (2004) - version=1.0

The original CellML model was created by:

Catherine Lloyd

[e-mail]

The University of Auckland

This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
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To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.